Amblyopia, also known as lazy eye, is a disorder of the visual system that is characterized by a vision deficiency in an eye that is otherwise physically normal, or out of proportion to associated structural abnormalities of the eye.
Amblyopia means that visual stimulation either fails to transmit or is poorly transmitted through the optic nerve to the brain for a continuous period of time. It can also occur when the brain "turns off" the visual processing of one eye, to prevent double-vision, for example in strabismus (crossed-eyes). It often occurs during early childhood, resulting in poor or blurry vision. Amblyopia normally affects only one eye in most patients. However, it is possible, though rare, to be amblyopic in both eyes, if both fail to receive clear visual images. Detecting the condition in early childhood increases the chance of successful treatment, especially if detected before the age of five. The earlier it is detected, and the underlying cause corrected with spectacles and/or surgery, the more successful the treatment in equalizing vision between the two eyes.Amblyopia is a developmental problem in the brain, not any intrinsic, organic neurological problem in the eyeball (although organic problems can lead to amblyopia which can continue to exist after the organic problem has resolved by medical intervention). The part of the brain receiving images from the affected eye is not stimulated properly and does not develop to its full visual potential. This has been confirmed by direct brain examination.
Many people with amblyopia, especially those who only have a mild form, are not even aware they have the condition until tested at older ages, since the vision in their stronger eye is normal. However, people who have severe amblyopia may experience related visual disorders, most notably poor depth perception. Amblyopes may suffer from poor spatial acuity, low sensitivity to contrast and some "higher-level" deficits to vision such as reduced sensitivity to motion.These deficits are usually specific to the amblyopic eye. Amblyopes also suffer from problems of binocular vision such as limited stereoscopic depth perception and usually have difficulty seeing the three-dimensional images in hidden stereoscopic displays such as autostereograms.However, perception of depth from monocular cues such as size, perspective, and motion parallax remains normal.
Amblyopia can be caused by deprivation of vision early in life by vision-obstructing disorders such as congenital cataracts, by strabismus (misaligned eyes), anisometropia (different degrees of myopia or hypermetropia in each eye), or by a significant amount of astigmatism in one or both eyes.
Treatment of strabismic or anisometropic amblyopia consists of correcting the optical deficit (wearing the necessary spectacle prescription) and often forcing use of the amblyopic eye, either by patching the good eye, or by instilling topical atropine in the eye with better vision.[13] Yet, there is a drawback as the drops can have a side-effect of creating nodules in the eye which a correctional ointment can counteract. One should also be wary of over-patching or over-penalizing the good eye when treating for amblyopia, as this can create so-called "reverse amblyopia" in the other eye.
Treatment of individuals age 9 through adult is possible through applied perceptual learning.
The term perceptual learning refers to the process of long lasting improvement in performing perceptual (visual, auditory, tactile, olfactory or taste) tasks as a function of experience.in Perceptual Learning, it is "the specific and relatively permanent modification of perception and behavior following sensory experience. It encompasses parts of the learning process that are independent from conscious forms of learning and involve structural and/or functional changes in primary sensory cortices." Such perceptual tasks range from simple discriminations along a single dimension (e.g. orientation discrimination in the visual modality, frequency discrimination in the auditory modality) to complex categorizations, which typically involve the integration of several dimensions (e.g. an X-ray image, with or without a tumor).
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